Increased circulating Th17 cells and elevated serum levels of TGF‐beta and IL‐21 are correlated with human non‐segmental vitiligo development

• DOI: 10.1111/pcmr.12355
• Publication Date: 2015-01-21T14:47:09Z
• Authors: Li Zhou; Yu‐Ling Shi; Kai Li; Iltefat Hamzavi; Tian‐Wen Gao; Richard H. Huggins; Henry W. Lim; Qing‐Sheng Mi
• Keywords: Vitiligo

Summary Although non‐segmental vitiligo ( NSV ) results from the autoimmune destruction of melanocytes, detailed immune mechanisms have not yet been fully elucidated. Th17 cells identified to be implicated in human diseases. In this study, frequencies peripheral blood and serum levels IL ‐17A cell‐related cytokines were examined 45 patients with active compared race‐, gender‐, age‐matched healthy controls. Our showed increased circulating cell elevated ‐17A, TGF ‐ β 1, ‐21 . Meanwhile, are positively correlated 1 level, body surface area lesions is frequencies. Furthermore, positive correlation was between Th1 These further indicate potential involvement collaborative contribution development, suggest that could contribute enhanced differentiation