PDCD1 gene polymorphisms as regulators of T‐lymphocyte activity in cutaneous melanoma risk and prognosis

• DOI: 10.1111/pcmr.12665
• Publication Date: 2017-11-01T07:36:38Z
• Authors: Gabriela V. B. Gomez; José A. Rinck‐Junior; Cristiane Oliveira; Dennis H. L. Silva; Ronei L. Mamoni; Gustavo J. Lourenço; Aparecida M. Moraes; Carmen S. P. Lima
• Keywords: Phototype

Summary This study aimed to evaluate whether PD1.1 (c.‐606G>A), PD1 (c.627 + 252C>T), PD1.5 (c.804C>T), and PD1.9 (c.644C>T) single nucleotide polymorphisms of PDCD1 gene influence the risk, clinicopathological aspects, survival cutaneous melanoma (CM). Individuals with phototype I or II CC genotype were under 5.89‐fold increased risk developing CM. TT expression (2.49 versus 1.28 arbitrary units, p = .03) CT allele T in TCD4 lymphocytes (16.6 12.5%, .01; 17.0 13.1%, .006). At 60 months follow‐up, short recurrence‐free was seen patients AA (33.3 71.8%, .03). Patients had 4.21 2.62 more chances presenting relapse evolving death by disease Cox analyses, respectively. Our data provide preliminary evidence that abnormalities regulation lymphocyte alter CM clinical prognosis.