MX 2 is a novel regulator of cell cycle in melanoma cells

• DOI: 10.1111/pcmr.12837
• Publication Date: 2019-10-29T09:56:49Z
• Authors: Marina Juraleviciute; Joanna Pozniak; Jérémie Nsengimana; Mark Harland; Juliette Randerso...; Patrik Wernhoff; Assia Bassarova; Geir Frode Øy; Gunhild Trøen; Vivi Ann Flørenes; David Timothy Bishop; Meenhard Herlyn; Julia Newton‐Bishop; Ana Slipicevic
• Keywords: Microphthalmia-associated transcription factor

MX2 protein is a dynamin-like GTPase2 that has recently been identified as an interferon-induced restriction factor of HIV-1 and other primate lentiviruses. A single nucleotide polymorphism (SNP), rs45430, in intron the gene, was previously reported novel melanoma susceptibility locus genome-wide association studies. Functionally, however, it still unclear whether how contributes to tumorigenesis. Here, we show differentially expressed tumors cell lines, with most metastatic lines showing lower expression than primary melanocytes. Furthermore, high RNA associated better patient survival. Overexpression reduces vivo proliferation partially through inhibition AKT activation, suggesting can act tumor suppressor melanoma. However, have also subset endogenous where downregulation leads reduced proliferation. In these cells, interfered DNA replication cycle processes. Collectively, our data for first time functionally involved regulation but its function context-dependent.