An In Vivo Study of LNS8801, a GPER Agonist, in a Spontaneous Melanoma‐Prone Mouse Model, TGS

• DOI: 10.1111/pcmr.13197
• Publication Date: 2024-09-16T10:40:22Z
• Authors: Christina Marinaro; John Sauer; Christopher A. Na...; Todd Ridky; Suzie Chen
• Keywords: GPER

ABSTRACT Melanoma is the most aggressive and deadly form of skin cancer that arises from transformation melanocytes, pigment producing cells skin. In year 2024 there will be approximately 10,000 new cases melanoma diagnosed 8,000 deaths attributed to in United States. this study we treated a group male female transgenic mice spontaneously develop metastatic melanoma, TGS, with G‐protein‐coupled estrogen receptor agonist LNS8801 assess efficacy on disease progression. A second TGS was also exposed UVB irradiation mimic exposure sunlight. Over course 32‐week experiment, visible images were taken by small animal imaging IVIS system track tumor progression, blood tissue samples collected for molecular analyses. Results showed sex‐biased effects observed shows UV‐protective influence both mice.