Maternal cerebellar gray matter volume is associated with daughters’ psychotic experience

• DOI: 10.1111/pcn.13011
• Publication Date: 2020-04-30T19:50:28Z
• Authors: Naoki Hashimoto; Timothy I. Michaels; Roeland Hancock; Ichiro Kusumi; Fumiko Hoeft
• Keywords: Voxel-based morphometry; Daughter; Gray (unit); Neurocognitive

Aim A substantial portion of children and adolescents show subthreshold psychotic symptoms called experience (PE). Because PE shares its biological environmental risk factors with spectrum disorders, parental neuroanatomical variation could reflect a heritable underpinning that may predict an offspring's PE. Methods total 94 participants from 35 families without diagnosis major neuropsychiatric disorders were examined, including 14 mother–daughter, 17 mother–son, 12 father–daughter, 16 father–son dyads. An was assessed the Atypicality subscale Behavior Assessment System for Children – 2nd Edition, Self‐Report Personality form (BASCaty). We examined correlations between voxel‐by‐voxel gray matter volume their BASCaty score. Results Maternal cerebellar using voxel‐based morphometry positively correlated daughters’ scores. The findings significant in more robust approach cerebellum‐specific normalization known. did not find correlation paternal scores or offspring volumes Conclusion Expanding upon parent‐of‐origin effects psychosis, maternal associated nature this sex‐specific intergenerational effect is unknown, but maternally transmitted genes relate cerebellum development to pathogenesis.