Pediatric maculopapular cutaneous mastocytosis: Retrospective review of signs, symptoms, and associated conditions

• DOI: 10.1111/pde.14399
• Publication Date: 2020-10-17T13:50:36Z
• Authors: Emily A. Gurnee; Maija L. Johansen; Thuy L. Phung; Emily L. Guo; Aaron Fong; Megha Tollefson; Henry Nguyen; Heather Brandling...; Natalie Moriarty; Amy S. Paller; Thy N. Huynh; Leslie P. Lawley
• Keywords: Cutaneous Mastocytosis; Tryptase; Maculopapular rash

Abstract Background/Objectives Though maculopapular cutaneous mastocytosis is the most common form of pediatric mastocytosis, it remains unclear which patients will experience severe symptoms. We sought to better define presentation and systemic signs symptoms in with mastocytosis. Methods analyzed retrospective data on 227 diagnosed prior age 15 years from five US clinical sites. collected signs, symptoms, onset, laboratory testing. Results Median onset was 3 months, 94% presenting 2 (range 0‐15 years). Patients before had significantly lower serum tryptase level ( P = .019). Greater number skin lesions .006), reported < .001), higher levels .001) were associated more Conclusion Children who have greater involvement, level, are likely