A Case of severe mosquito bite allergy complicated by fatal hemophagocytic lymphohistiocytosis

• DOI: 10.1111/pde.14877
• Publication Date: 2022-03-24T21:45:10Z
• Authors: Elizabeth Dupuy; Ladan Afifi; Steven J. Jonas; Carol E. Cheng; Marcia Hogeling
• Keywords: Hemophagocytic Lymphohistiocytosis

Severe mosquito bite allergy (SMBA) is characterized by necrotic skin lesions and systemic symptoms. Chronic active Epstein-Barr virus (EBV) infection, when superimposed with SMBA, a key driver for catastrophic clinical consequences, such as uncontrolled lymphoproliferation. This interplay of significance due to its association hemophagocytic lymphohistiocytosis (HLH) and/or EBV-driven malignancies. Here, we report case SMBA that developed in 14-year-old Hispanic boy led fatal secondary HLH.