Therapeutic response of iNO in preterm infants with hypoxemic respiratory failure

• DOI: 10.1111/ped.15423
• Publication Date: 2022-11-22T10:34:07Z
• Authors: Shuntaro Oka; Eri Nishimura; Junichi Ozawa; Mitsuhiro Haga; Naoyuki Miyahara; Shun Sakatani; Yohei Minamitani; Fumihiko Namba
• Keywords: Bronchopulmonary Dysplasia; Oxygenation index

Inhaled nitric oxide (iNO) has been used as a rescue treatment for preterm infants with hypoxemic respiratory failure (HRF). However, its effectiveness remains debatable. Thus, in this study, we aimed to examine the impact of iNO therapy on HRF extremely infants.A retrospective observational study was performed. Extremely admitted our neonatal intensive care unit who received later their postnatal life were included. The oxygen saturation index (OSI) an severity failure.In total, 30 included study. Oxygenation enhanced after administration HRF. OSI decreased by more than 20% 12 patients (40%, positive responder) and did not decrease 17 (57%, negative within first 6 h treatment. initiation day significant independent factor associated response HRF.iNO effective enhancing oxygenation Earlier use therapeutic iNO, implying that may be pulmonary vessels which are less damaged shorter-term mechanical ventilation.