Cardiometabolic risks vary by weight status in pediatric kidney and liver transplant recipients: A cross‐sectional, single‐center study in the USA

• DOI: 10.1111/petr.12984
• Publication Date: 2017-07-18T04:02:52Z
• Authors: S. He; N. A. Le; J. K. Frediani; P. D. Winterberg; R. Jin; R. Liverman; A. Hernandez; R. L. Cleeton; M. B. Vos
• Keywords: Cross-sectional study

Abstract There is an increasing need to understand long‐term metabolic changes and resultant comorbidities because life expectancy after pediatric kidney liver transplants. We evaluated differences in classic novel cardiometabolic biomarkers among obese normal weight adolescent transplant recipients. enrolled a total of 80 (mean±SD, 14.8 years ±3.0) recipients (63 kidney, 17 liver) with mean duration from transplantation 6.0 (±4.1) years. Among recipients, overweight individuals had higher leptin (16.7 vs 7.5 μg/mL, P <.001), lower HDL (1.1 1.3 mmol/L, =.02), free fatty acid (0.6 0.5 =.03), apoB‐to‐apoA1 ratio (0.8 0.6, glucose (5.8 4.3 =.03) concentrations compared individuals. Regardless obesity status, over half all participants (57.5%) were considered at high risk using consensus guidelines, this was more pronounced for (61.9%). Post‐transplantation adolescents have increased characterized by traditional factors diabetes. The presence significantly worsens risk. Future studies should explore whether treatment can improve the health outcomes children undergoing solid organ transplant.