Factors associated with immune hemolytic anemia after pediatric liver transplantation

• DOI: 10.1111/petr.13230
• Publication Date: 2018-06-09T02:05:54Z
• Authors: Nathalie Rock; Marc Ansari; Jean Villard; Sylvie Ferrari‐La...; Sophie Waldvogel; Valérie Anne McLin
• Keywords: Univariate analysis

Immune-mediated hemolytic anemia following SOT is a rare disorder, the risk factors for which are unknown. Our purpose was to analyze seemingly increased incidence in our center with aim identify predisposing factors. This recipients single-center retrospective study reviewed medical records of 96 pediatric LT between 2000 and 2013. IHA defined as acute positive direct antiglobulin test. Seven cases immune-mediated were identified (incidence 8.5%). Three presented during first 3 months (early IHA), 4 later (late IHA). All patients late required rituximab. Using univariate analysis, associated onset: BA (P = .04), younger age use IGL-1 preservation solution .05). Late viral infections occurring beyond LT, age, .01). Overall, CMV infection development both early IHA: CMV-negative who received an organ from CMV-positive donor more likely develop .035), de novo year post-LT .03). complication frequently initial diagnosis BA. experience seem particularly vulnerable. may be likelihood developing IHA, novel finding warrants further investigation.