Full left/full right liver graft ex situ split during hypothermic oxygenated perfusion

• DOI: 10.1111/petr.14284
• Publication Date: 2022-04-19T05:59:43Z
• Authors: Guillaume Rossignol; Xavier Muller; Kayvan Mohkam; Remi Dubois; Mickaël Lesurtel; Jean‐Yves Mabrut
• Keywords: Machine Perfusion; Ex vivo

Ex vivo split liver transplantation in pediatric recipients has shown inferior results compared with whole grafts. One factor among others contributing to grafts being considered as marginal is the prolonged static cold storage time related ex splitting. End ischemic hypothermic oxygenated perfusion a validated strategy improve outcomes of and may thus also benefit grafts.We present first case full left/full right procedure performed during perfusion.We standardized surgical two-step approach where parenchymal transection was end via portal vein shorten duration. Both were successfully transplanted 4-year-old 38-year-old adult recipient. Despite high-risk (retransplantation), extended donor criteria including cardiac arrest high risk index (2,25), both showed early recovery hepatic function low serum transaminase release. At 6 months, alive normal biology functioning graft.Although challenging, can be promising post-transplant outcomes.