Full left/full right liver graft ex situ split during hypothermic oxygenated perfusion
[SDV] Life Sciences [q-bio]
0301 basic medicine
03 medical and health sciences
0302 clinical medicine
3. Good health
DOI:
10.1111/petr.14284
Publication Date:
2022-04-19T05:59:43Z
AUTHORS (6)
ABSTRACT
AbstractBackgroundEx vivo split liver transplantation in pediatric recipients has shown inferior results compared with whole grafts. One factor among others contributing to split grafts being considered as marginal is the prolonged static cold storage time related to ex vivo liver splitting. End ischemic hypothermic oxygenated perfusion is a validated strategy to improve outcomes of marginal whole grafts and may thus also benefit split liver grafts.MethodWe present the first case of full left/full right split procedure performed during hypothermic oxygenated perfusion.ResultsWe present a standardized surgical two‐step approach where parenchymal transection was performed during end ischemic hypothermic oxygenated perfusion via the portal vein to shorten static cold storage duration. Both split grafts were successfully transplanted in a 4‐year‐old pediatric and a 38‐year‐old adult recipient. Despite high‐risk procedure (retransplantation), extended donor criteria including a prolonged cardiac arrest and high donor risk index (2,25), both grafts showed early recovery of hepatic function and low serum transaminase release. At 6 months, both recipients were alive with a normal liver biology and a functioning graft.ConclusionAlthough challenging, full left/full right liver split procedure during end ischemic hypothermic oxygenated perfusion can be successfully performed and is a promising strategy to improve post‐transplant outcomes.
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