Constructing an Intent‐to‐Treat Score Index to Predict Survival Outcomes in Pediatric Liver Transplant Recipients

• DOI: 10.1111/petr.14816
• Publication Date: 2024-06-24T10:49:30Z
• Authors: Ashley Montgomery; Anna Lang; Bhavana Kunisetty; Spoorthi Kamepalli; Jake Lynn; Alexandra Alvarez; John Goss; Nhu Thao Nguyen G...; Abbas Rana
• Keywords: Liver disease; Univariate analysis

ABSTRACT Background Waitlist and posttransplant outcomes have been widely reported for pediatric liver transplantation. Yet, analyzing these metrics individually fails to provide a holistic perspective patients their families. Intent‐to‐treat (ITT) analysis fills this gap by studying the associations between waitlist outcomes, organ availability, outcomes. Our study aimed construct predictive index utilizing ITT transplant recipients (Pedi‐ITT). Methods We performed retrospective de‐identified data provided United Network Organ Sharing (UNOS) from March 1, 2002, December 31, 2021. analyzed 12 926 (age <18). conducted univariate multivariable logistic regression find significant factors affecting survival. A scoring was constructed stratify outcome risk on basis of identified analysis. Results Multivariable found following be significantly associated with death or after transplant: gender, diagnosis, UNOS region, ascites, diabetes mellitus, age at time listing, serum sodium total bilirubin creatinine INR history ventilator use, re‐transplantation. Using receiver operator characteristic analysis, Pedi‐ITT had c ‐statistic 0.79 (95% confidence interval [CI]: 0.76–0.82). The ‐statistics Model End‐Stage Liver Disease/Pediatric Disease version Survival Outcomes Following Transplantation score indices were 0.74 (CI: 0.71–0.76) 0.69 0.66–0.72), respectively. Conclusions provides an additional prognostic model moderate power assess Further should focus increasing index.