Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice

Transepidermal water loss Hairless Barrier function Photoaging
DOI: 10.1111/phpp.12051 Publication Date: 2013-07-02T04:44:03Z
ABSTRACT
Summary Background Ultraviolet B ( UVB ) irradiation induces serious damage to the skin. Collagen hydrolysate and collagen‐derived peptides have effects on skin function in vivo vitro . However, few studies investigated changes epidermal barrier or dermal elasticity caused by Here, we loss of induced hairless mice fed collagen hydrolysate. Methods Mice were orally administered hydrolysate, a single dose (20 mJ/cm 2 repeated doses (10–30 , 3 times/week for 6 weeks), dorsal was exposed Skin measurements histological analytical performed. Results In control mice, dysfunction including an increase transepidermal water TEWL ), hyperplasia, decrease stratum corneum content. Administration significantly decreased thickness increased Repeated hyaluronic acid HA content whereas suppressed both improved Conclusions administration affects elasticity.
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