Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice

• DOI: 10.1111/phpp.12051
• Publication Date: 2013-07-02T04:44:03Z
• Authors: Chisato Oba; Hiroki Ohara; Masashi Morifuji; Kyoko Ito; Satomi Ichikawa; Keiko Kawahata; Jinichiro Koga
• Keywords: Transepidermal water loss; Hairless; Barrier function; Photoaging

Summary Background Ultraviolet B ( UVB ) irradiation induces serious damage to the skin. Collagen hydrolysate and collagen‐derived peptides have effects on skin function in vivo vitro . However, few studies investigated changes epidermal barrier or dermal elasticity caused by Here, we loss of induced hairless mice fed collagen hydrolysate. Methods Mice were orally administered hydrolysate, a single dose (20 mJ/cm 2 repeated doses (10–30 , 3 times/week for 6 weeks), dorsal was exposed Skin measurements histological analytical performed. Results In control mice, dysfunction including an increase transepidermal water TEWL ), hyperplasia, decrease stratum corneum content. Administration significantly decreased thickness increased Repeated hyaluronic acid HA content whereas suppressed both improved Conclusions administration affects elasticity.