Proteomics analysis to investigate the potential mechanism of theacrine against UV‐induced skin photodamage

• DOI: 10.1111/phpp.12908
• Publication Date: 2023-08-29T07:26:57Z
• Authors: Yong He; Xinkai Zheng; Yunfeng Hu; Liehua Deng; Jin Xu; Shi Wu
• Keywords: Proteomics; Molecular Docking Simulation; Mice; Mice, Inbred ICR; Caspase 3; Animals; Apoptosis Regulatory Proteins

This study aimed to explore the underlying mechanism of theacrine treatment UV-induced skin photodamage.Tandem Mass Tag (TMT) relative quantitative proteomics analysis was used characterize proteins and pathways associated with ability combat photodamage in mouse by modeling UV irradiation backs ICR mice.Apoptosis-related signaling play a key role protect against photodamage, according proteomic bioinformatics analysis; molecular docking Western blotting further revealed that apoptosis-related (p53, Bcl-2, Bax, caspase-3, cleaved-caspase-3) strong binding affinity, which can significantly reduce cell apoptosis induced exposure.The findings UVB-induced epidermal damage controlling pathway, implying could be useful anti-UVB agent.