Cytotoxic cell involvement in human cutaneous leishmaniasis: assessments in active disease, under therapy and after clinical cure

• DOI: 10.1111/pim.12312
• Publication Date: 2016-03-01T06:06:29Z
• Authors: C. F. Cunha; R. Ferraz; M. I. F. Pimentel; M. R. Lyra; A. O. Schubach; A. M. Da‐Cruz; A. L. Bertho
• Keywords: Adult; Cytotoxicity, Immunologic; Male; Meglumine Antimoniate; Antiprotozoal Agents; Leishmaniasis, Cutaneous; Middle Aged; Cell Degranulation; Leishmania braziliensis; CD4 Lymphocyte Count; 3. Good health; Killer Cells, Natural; Young Adult; 03 medical and health sciences; Meglumine; 0302 clinical medicine; Organometallic Compounds; Humans; Natural Killer T-Cells; Female; Cells, Cultured

Summary Cutaneous leishmaniasis ( CL ) is an important public health issue worldwide. The control of Leishmania infection depends on cellular immune mechanisms, and the inflammatory response may contribute to pathogenesis. A beneficial role CD 8 + T lymphocytes has been proposed; nevertheless, other studies suggest a cytotoxic involved in tissue damage, showing controversial these cells. goal current study was understand immunopathology determine profile cells – such as 4 T, natural killer that might be triggering immunological lead cure or disease progression. frequencies cell populations peripheral blood, obtained from patients with active disease, during treatment after clinical healing, were assessed by flow cytometry. Cytotoxicity could not related deleterious braziliensis infection, showed similar percentages degranulation healthy individuals (HI). Cured exhibited lower percentage degranulating cells, which due downregulation response. understanding immunopathological mechanisms commitment enables improvements therapeutic strategies.