Protection and immunological study on two tetraspanin‐derived vaccine candidates against schistosomiasis japonicum
Tetraspanin
Schistosoma
CD81
DOI:
10.1111/pim.12338
Publication Date:
2016-05-18T12:55:31Z
AUTHORS (10)
ABSTRACT
Tetraspanins (TSPs) are proteins found on the surface of helminth parasites genus Schistosoma and regarded as potentially protective antigens. The large extracellular loop mansoni tetraspanin-2, Sm-TSP-2, when fused to a thioredoxin partner formulated with Freund's adjuvants, has been shown be an efficacious vaccine against murine schistosomiasis. It is well recognized that CD4(+) T-cell-dependent immunity might play important role schistosomes; however, contribution CD8(+) T cells multicellular pathogen still uncertain. exogenous protein-pulsed dendritic (DCs) can easily activate response, while response was relatively difficult induced. In this study, we evaluated immunogenicity TSP2HD antigen (hydrophilic domain S. japonicum tetraspanin-2) TAT (the protein transduction HIV-1)-coupled protein. As TAT-fused could promote major histocompatibility complex class I-dependent presentation in vitro, TAT-TSP2HD-pulsed DCs induced stronger proliferation schistosome-specific compared incubated alone. Vaccination vivo improve disease outcome japonicum-infected mice slightly superior vaccination treated TSP2HD. summary, these data showed fusion help Th1 provide part protection schistosome.
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