Strongyloides‐specific IgA, IgG and IgG immune complex profile in patients with pulmonary tuberculosis

• DOI: 10.1111/pim.12793
• Publication Date: 2020-09-24T11:58:39Z
• Authors: Larissa Rodrigues...; Gabriela Borges d...; Henrique Tomaz Go...; Ana Lúcia Ribeiro...; Luiz Antonio Cust...; Wander Rogério Pa...; Ivete Conchon‐Costa; Fabiana Martins d...; Julia Maria Costa...; Idessania Nazaret...
• Keywords: Adult; Male; Antibodies, Protozoan; Enzyme-Linked Immunosorbent Assay; Antigen-Antibody Complex; Middle Aged; Immunoglobulin A; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Immunoglobulin G; Larva; Strongyloides; Strongyloidiasis; Animals; Humans; Female; Saliva; Tuberculosis, Pulmonary

AbstractAimsTo describe an anti‐StrongyloidesIgA, IgG and IgG immune complex antibody response profile in patients with pulmonary tuberculosis.Methods and ResultsSaliva and serum samples were collected from 100 individuals: group I, 50 apparently healthy individuals; and group II, 50 pulmonary tuberculosis patients. The IgA, IgG and IgG immune complex detection were carried out via an ELISA immunoenzymatic test. Optical density medians in saliva samples of IgA antibody (median of 7.21) and IgG‐IC (median of 4.95) were significantly higher in tuberculosis group compared to control individuals (median IgA of 3.93 and IgG‐IC of 2.38).ConclusionThis study presents antibody data to the field of pulmonary tuberculosis and strongyloidiasis coinfection, including saliva samples, and especially IgG immune complex detection.