The difference of neovascularization in early intra‐alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia

• DOI: 10.1111/pin.12058
• Publication Date: 2013-05-29T06:57:09Z
• Authors: Mikiko Takahashi; Shinobu Kunugi; Yasuhiro Terasaki; Mika Terasaki; Hirokazu Urushiyama; Naomi Kuwahara; Kyoko Wakamatsu; Tomoko Nakayama; Yuh Fukuda
• Keywords: Usual interstitial pneumonia; Idiopathic interstitial pneumonia; Pathogenesis; Diffuse alveolar damage

Of the idiopathic interstitial pneumonias ( IIPs ), usual pneumonia UIP ) and diffuse alveolar damage DAD usually have poor prognoses. The prognoses of cryptogenic organizing COP nonspecific NSIP are more favorable. Although several reports described neovascularization in , this aspect has not been compared with . In study, we evaluated intra‐alveolar fibrotic lesion cases fibrosing (f‐ n = 26) 25). f‐ group, a considerable degree was observed to group bud type fibrosis showed greater mural‐incorporation obliterative types fibrosis. Real‐time reverse transcription polymerase chain reaction revealed significantly expression VEGF ‐ A mRNA than matrix metalloproteinase‐2 MMP ‐2) also higher ‐2 may play role pathogenesis early lesions