Changes in Clinical Pain in Fibromyalgia Patients Correlate with Changes in Brain Activation in the Cingulate Cortex in a Response Inhibition Task

• DOI: 10.1111/pme.12460
• Publication Date: 2014-07-04T11:30:46Z
• Authors: Tobias Schmidt-Wi...; Anson Kairys; Eric Ichesco; Maria Luisa Ferna...; Paloma Barjola; Mary Heitzeg; Richard E. Harris; Daniel J. Clauw; Jennifer Glass; David A. Williams
• Keywords: Cingulate cortex; Posterior cingulate; Supplementary motor area; Premotor cortex

ObjectiveThe primary symptom of fibromyalgia is chronic, widespread pain; however, patients report additional symptoms including decreased concentration and memory. Performance-based deficits are seen mainly in tests working memory executive functioning. It has been hypothesized that pain interferes with cognitive performance; the neural correlates this interference still a matter debate. In previous, cross-sectional study, we reported (as compared healthy controls) showed blood oxygen level dependent (BOLD) response related to inhibition (in simple Go/No-Go task) anterior/mid cingulate cortex, supplementary motor area, right premotor cortex.