Cohort profile update: The Canadian Maternal–Infant Research on Environmental Chemicals Child Development study (MIREC‐CD PLUS)

• DOI: 10.1111/ppe.13013
• Publication Date: 2023-11-03T12:40:30Z
• Authors: Mandy Fisher; Gina Muckle; Bruce Lanphear; Tye E. Arbuckle; Joseph M. Braun; Angelika Zidek; Maria P. Vélez; Nicole Lupien; Stephanie Bastien; Jillian Ashley‐Ma...; Youssef Oulhote; Michael M. Borghese; Mark Walker; Elizabeth Asztalos; Maryse F. Bouchard; Linda Booij; Mark R. Palmert; Katherine M. Morr...; Elizabeth A. Cumm...; Karine Khatchadou...; Constadina Panagi...; Gord Glendon; Robin Shutt; Ammanie Abdul‐Fatah; Kelsey Seal; William D. Fraser
• Keywords: Toddler; Child Development

Abstract Background The pan‐Canadian Maternal–Infant Research on Environmental Chemicals (MIREC) study was established to determine whether maternal environmental chemical exposures were associated with adverse pregnancy outcomes in 2001 pregnant women. Objectives MIREC‐Child Development (CD PLUS) followed this cohort the goal of assessing potential effects prenatal anthropometry and neurodevelopment early childhood. Population MIREC families children between ages 15 months 5 years who had agreed be contacted for future research ( n = 1459) invited participate MIREC–CD PLUS which combines data collected from an online Maternal Self‐Administered Questionnaire biomonitoring two in‐person visits. Preliminary Results Between April 2013 March 2015, 803 participated Biomonitoring visit where we anthropometric measures, blood, urine children. Behavioural Assessment System Children‐2, Behaviour Rating Inventory Executive Function, MacArthur‐Bates Communicative Inventories Communication subscale Adaptive Scale Bayley Scales Infant Toddler Development‐III are available close 900 There 610 singleton completed visits assessments including Social Responsiveness Scale, Wechsler Preschool Primary Intelligence‐III NEuroPSYchological (NEPSY). Currently, following into adolescence measure impact life endocrine metabolic function (MIREC–ENDO). Conclusions Data collection is complete analysis continues. We now extending follow‐up limited by loss fact that mothers predominately higher socioeconomic status ‘White’ ethnicity, limits our generalizability. However, depth clinical measures provides a platform examine associations prenatal, infancy childhood child growth development.