Attenuated Doors‐Locked P300 Amplitude and Elevated Depressive Symptoms: Effects of Age and Sex in Two Independent Samples of Youth

• DOI: 10.1111/psyp.70009
• Publication Date: 2025-02-03T03:39:56Z
• Authors: Nicholas J. Santo...; Nader Amir; Brady D. Nelson; Daniel N. Klein; Greg Hajcak
• Keywords: Doors

Deficits in cognitive and reward-related functions, measured via reductions the P300 reward positivity (RewP) event-related potential (ERP) components, are commonly observed adults suffering with depression. Considering higher risk for depression emerges among females adolescence, examination of neurological underpinnings during this critical developmental period can help further elucidate our overall understanding etiology depressive disorders. Therefore, present study sought to first examine associations between doors-locked amplitude, RewP current symptoms, age an all-female youth sample (sample 1: n = 296; age, 8 14). Next, we examined these same associations, as well sex, a second independent consisting male female youths 2: 605; 11 Blunted was associated symptoms both samples. Moreover, association stronger older Sex moderated relationship 2 such that smaller related greater only females. There were no consistent amplitude either sample. These findings suggest component is reliable neural correlate might specifically relate pathways linked increased adolescent