Altered insulin, leptin and ghrelin hormone levels and atypical estrous cycle lengths in two highly fertile mouse lines

• DOI: 10.1111/rda.14097
• Publication Date: 2022-02-13T18:34:06Z
• Authors: Michela Calanni‐P...; Joachim M. Weitzel; Martina Langhammer; Erika Wytrwat; Marten Michaelis
• Keywords: Control line; Litter

Mouse models of decreased fertility mainly support scientific knowledge in the field reproductive biology. In this study, we changed perspective, using Dummerstorf high-fertility mouse lines FL1 and FL2 selected for increased performances that doubled amount ovulated oocytes per cycle number offspring litter compared to an unselected control line (founder population, FZTDU, ctrl). After recent observations, both seem show a lower pregnancy rate ctrl together with atypical cycle. We analysed estrous those mice, but also plasma levels insulin, glucagon, leptin ghrelin that, when irregular, may have impact on length by modifying GnRH release. included females another independent (DU6P), from same founder population independently traits, as additional model rate. aim evaluate if do they use similar mechanism associated regulation or implicated altered control, because situation does, even without increase parameters. speculate FLs' undergoes changes during selection period demonstrate some hormonal dysfunctions link cycle, dampened rates reduced first delivery mostly FL2, higher-fertility phenotype rather than FLs.