Roles of Ki‐67, p53, transforming growth factor‐β and lysyl oxidase in the metastasis of lung cancer

• DOI: 10.1111/resp.12345
• Publication Date: 2014-07-04T02:53:45Z
• Authors: Omer Araz; Elif Demirci; Elif Yilmazel Ucar; Muhammet Calik; Adem Karaman; Irmak Durur‐Subasi; Ebru Orsal; Mahmut Subasi; Ferah Daloglu; Metin Akgun
• Keywords: Lysyl Oxidase

Most lung cancer (LC) patients have metastatic disease at time of diagnosis, which influence the treatment regimen and is most important prognostic factor. The main purpose our study was to evaluate relationship between cell proliferation (Ki-67 label index), p53, transforming growth factor-β (TGF-β) lysyl oxidase (LOX), stages different cancers. secondary aim correlate these parameters with standardized uptake value (SUVmax) primary lesion during positron emission tomography-computed tomography (PET-CT).Eighty-five treatment-naive LC were enrolled. All examined PET-CT. Ki-67, TGF-β LOX evaluated histopathologically.Small (SCLC) showed intense staining in all parameters. A well-differentiated adenocarcinoma (AC) demonstrated a more diffuse than squamous carcinoma (SCC). There no statistically significant four metastases SCLC SCC. However, TGF-β, AC regards diffusivity intensity. p53 Ki-67 did not show relationship. No correlation SCC SUVmax found. AC, intensity SUVmax.LOX may play roles AC. become markers inhibition could be explored for treatment.