Comorbidities in difficult asthma are independent risk factors for frequent exacerbations, poor control and diminished quality of life
Adult
Male
Depression
Statistics as Topic
Australia
610
Comorbidity
Middle Aged
Rhinitis, Allergic
Risk Assessment
Severity of Illness Index
Asthma
3. Good health
Body Mass Index
03 medical and health sciences
Sleep Apnea Syndromes
0302 clinical medicine
Risk Factors
616
Outcome Assessment, Health Care
Gastroesophageal Reflux
Quality of Life
Humans
Female
Aged
DOI:
10.1111/resp.12838
Publication Date:
2016-07-01T01:13:07Z
AUTHORS (7)
ABSTRACT
Little is known about how comorbidities affect difficult asthma patients across different domains of outcomes. We hypothesized that in significantly influence outcomes.We analysed 90 consecutive who underwent systematic assessment at our hospital's clinic. Eight were assessed all patients. They allergic rhinitis, chronic rhinosinusitis (CRS), gastroesophageal reflux disease, obesity, obstructive sleep apnoea, anxiety or depression, dysfunctional breathing (DB) and vocal cord dysfunction (VCD). Asthma outcomes examined exacerbation frequency (≥3/year vs <3/year), control using the Control Test (ACT) quality life Quality Life Questionnaire (AQLQ). Multivariate logistic regression was performed for dichotomous linear continuous Analyses adjusted lung function absolute blood eosinophils.Increasing BMI an independent risk factor exacerbations (OR: 1.1, 95% CI: 1-1.1, P = 0.042), lower ACT score (β coefficient: -0.25, -0.37 to -0.12, < 0.001) poorer AQLQ -0.05, -0.09 -0.02, 0.006). DB predicted -2.85, -5 -0.7, 0.01) scores -0.73, -1.34 0.02). Patients with CRS had more 4, 1.5-10.9, VCD -0.78, -1.38 -0.18, 0.012).Comorbidities independently impact a broad spectrum asthma. Systematic evaluation these conditions essential
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (40)
CITATIONS (156)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....