Diagnostic performance of endobronchial ultrasound‐guided mediastinal lymph node sampling in early stage non‐small cell lung cancer: A prospective study

• DOI: 10.1111/resp.13162
• Publication Date: 2017-08-31T11:51:09Z
• Authors: Macarena R. Vial; Oisin J. O'Connell; Horiana B. Grosu; Mike Hernandez; Laila Noor; Roberto F. Casal; John Stewart; Mona Sarkiss; Carlos A. Jimenez; David Rice; Reza Mehran; David E. Ost; George A. Eapen
• Keywords: Endobronchial ultrasound; Mediastinal lymph node; Lung cancer staging; Mediastinal lymphadenopathy

ABSTRACT Background and objective Standard nodal staging of lung cancer consists positron emission tomography/computed tomography ( PET / CT ), followed by endobronchial ultrasound‐guided transbronchial needle aspiration EBUS‐TBNA ) if shows mediastinal lymphadenopathy. Sensitivity in patients with N0 N1 disease is unclear largely based on retrospective studies. We assessed the sensitivity this setting. Methods enrolled proven or suspected staged as without metastatic M0 who underwent . Primary outcome was compared a composite reference standard surgical stage EBUS demonstrated N2 N3 disease. Results Seventy‐five were included analysis. Mean tumour size 3.52 cm (±1.63). Fifteen 75 (20%) had identified six while nine only at surgery. for 40% (95% CI : 16.3–67.7%). Conclusion A significant proportion substantial fraction these patients, thus improving diagnostic accuracy alone. however appears lower historical data from larger volume Therefore, strategies to improve population should be further explored