Minimal important difference of target lobar volume reduction after endobronchial valve treatment for emphysema

• DOI: 10.1111/resp.13178
• Publication Date: 2017-09-15T07:03:10Z
• Authors: Jorrit B.A. Welling; Jorine E. Hartman; Eva M. van Rikxoort; Nick H.T. Ten Hacken; Huib A.M. Kerstjens; Karin Klooster; Dirk‐Jan Slebos
• Keywords: Lung volume reduction; Residual volume

Target lobar volume reduction (TLVR) is an important efficacy outcome measure for bronchoscopic lung (BLVR) treatment using one-way endobronchial valves (EBV) in patients with severe emphysema. The commonly used cut-off value TLVR that expresses a perceivable clinical benefit -350 mL. However, scientifically determined minimal difference (MID) never has been published. objective of the present study was to determine MID on HRCT who were treated EBV.A total 318 emphysema from two BLVR trials analysed. Anchor-based methods define at 6 months follow-up. Forced expiratory 1 s (FEV1 ), residual (RV) and St. George's Respiratory Questionnaire (SGRQ) as anchors.The calculated each anchor was: FEV1 -587 mL, RV -534 mL SGRQ -560 combined (average three anchor-based MIDs) -563 mL.Using method, we established follow-up after EBV treatment. This can be useful both interpreting results practice, well designing future studies reduction.