Treatable traits can be identified in a severe asthma registry and predict future exacerbations

• DOI: 10.1111/resp.13389
• Publication Date: 2018-09-19T09:24:29Z
• Authors: Vanessa M. McDonald; Sarah A. Hiles; Krystelle Godbout; Erin S. Harvey; Guy B. Marks; Mark Hew; Matthew Peters; Philip G. Bardin; Paul N. Reynolds; John W. Upham; Melissa Baraket; Zaheerodin Bhikoo; Jeffrey Bowden; Ben Brockway; Li Ping Chung; Belinda Cochrane; Gloria Foxley; Jeffrey Garrett; Lata Jayaram; Christine Jenkins; Constance Katelaris; Gregory Katsoulotos; Mariko S. Koh; Vicky Kritikos; Marina Lambert; David Langton; Alexis Lara Rivero; Peter G. Middleton; Aldoph Nanguzgambo; Naghmeh Radhakrishna; Helen Reddel; Janet Rimmer; Anne Marie Southcott; Michael Sutherland; Francis Thien; Peter A.B. Wark; Ian A. Yang; Elaine Yap; Peter G. Gibson
• Keywords: Asthma Exacerbations

ABSTRACT Background and objective A new taxonomic management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether traits could be identified using registry data particular were associated with future exacerbation risk. Methods The Australasian Severe Asthma Web‐Based Database (SAWD) enrolled 434 participants asthma a comparison group of 102 non‐severe Published mapped to fields their prevalence was described. Participants characterized at baseline every 6 months 24 months. Results In SAWD, in three domains: pulmonary, extrapulmonary behavioural/risk factors. Patients expressed more pulmonary than Allergic sensitization, upper‐airway disease, airflow limitation, eosinophilic inflammation frequent exacerbations common Ten predicted risk; among the strongest being prone exacerbations, depression, inhaler device polypharmacy, vocal cord dysfunction obstructive sleep apnoea. Conclusion Treatable can assessed registry. asthma, patients express Traits may risk demonstrating clinical utility assessing traits.