Predicting malignant pleural effusion during diagnostic pleuroscopy with biopsy: A prospective multicentre study

• DOI: 10.1111/resp.14232
• Publication Date: 2022-02-18T06:12:54Z
• Authors: Horiana B. Grosu; Ryan Kern; Fabien Maldonado; Roberto Casal; Clark R. Andersen; Liang Li; Georgie Eapen; David Ost; Carlos Jimenez; Frangiskos Frango...; Bruce Sabath; Erik Vakil; Audra Schwalk; Mathieu Marcoux; Ala Eddin Sagar; Faria Nasim; Julie Lin; Moiz Salahudin; Hasan Muhammad Arain; Laila Noor; Diana Montanez; John Stewart; John Mullon; Michalis Michael; Ilias Porfyridis
• Keywords: Thoracoscopy

Pleuroscopy with pleural biopsy has a high sensitivity for malignant effusion (MPE). Because MPEs tend to recur, concurrent diagnosis and treatment of MPE during pleuroscopy is desired. However, proceeding directly at the time requires confidence in on-site diagnosis. The study's primary objective was create predictive model estimate probability pleuroscopy.A prospective observational multicentre cohort study consecutive patients undergoing conducted. We used logistic regression evaluate relation visual assessment, rapid evaluation (ROSE) touch preparation presence nodules/masses on computed tomography (CT). To assess model's prediction accuracy, bootstrapped training/testing approach utilized cross-validated area under receiver operating characteristic curve.Of 201 included study, 103 had MPE. Logistic showed that higher level malignancy assessment associated odds (OR = 34.68, 95% CI 9.17-131.14, p < 0.001). also ROSE 11.63, 3.85-35.16, Presence CT 6.61, 1.97-22.1, 0.002). A multivariable final pathologic status AUC 0.94 (95% 0.91-0.97).A using scan findings demonstrated excellent accuracy Further validation studies are needed confirm our findings.