Combining small airway parameters with conventional parameters obtained during spirometry to diagnose airflow obstruction: A cross‐sectional study

• DOI: 10.1111/resp.14725
• Publication Date: 2024-04-24T23:55:10Z
• Authors: Zhufeng Wang; Junfeng Lin; Lina Liang; Yun Li; Jinhai Huang; Yi Gao; Jinping Zheng
• Keywords: Vital capacity; Cross-sectional study; Airway obstruction

Abstract Background and Objective The use of small airway parameters generated by spirometry, namely forced expiratory flow between 25% 75% vital capacity (FVC) (FEF 25%–75% ) at 50% FVC FEF , respectively), is widely discussed. We evaluated the importance these spirometric in a large Chinese population. Methods conducted cross‐sectional observational study which spirometry bronchodilator responsiveness (BDR) data were collected healthcare centre from May 2021 to August 2022 tertiary hospital January 2017 March 2022. Discordance was assessed classification test results volume 1 second (FEV FEV /FVC ratio . predictive power Z‐scores for airflow limitation BDR using receiver operating characteristic curves. Results Our included 26,658 people. Among people with normal ( n = 14,688), 3.7%, 4.5% 3.6% cases exhibited but impaired respectively, while 6.8%–7.0% Using combining both showed best area under curve predicting (0.90; 95% CI 0.87–0.94) (0.72; 0.71–0.73). Conclusion It important consider avoid missing diagnosis obstruction. image