Framework to Evaluate Exposure Relevance and Data Needs for Risk Assessment of Nanomaterials using in Vitro Testing Strategies

• DOI: 10.1111/risa.12581
• Publication Date: 2016-02-24T20:04:19Z
• Authors: Monita Sharma; Jo Anne Shatkin; Carolyn Cairns; Richard Canady; Amy J. Clippinger
• Keywords: Relevance; Test strategy

This article presents a multistage framework for evaluating the strength of evidence nanomaterial (NM) exposure characterization data to optimize utility in vitro testing strategies human health risk assessment. is intended aid assessors relevance from tests and development new strategies. The initial stage frames scenarios interest advance incorporate aspects such as release points, route exposure, biological environmental transformations, dose metrics, targets subsequent stages. second considers context realistic third involves designing strategy based on expected conditions. For fourth final stage, we propose matrix approach evaluate obtained first three stages basis determining best combination test conditions analytical methods available characterize measure NM type. can also be used existing their scenario further develop Implementation proposed will generate meaningful information properties interaction with systems, scenarios, which cost effective applied assessing making intelligent regulatory decisions regarding use disposal NMs.