Activation of Complement Following Total Hip Replacement

• DOI: 10.1111/sji.12411
• Publication Date: 2016-01-04T10:12:24Z
• Authors: S. Thordardottir; T. Vikingsdottir; H. Bjarnadottir; H. Jonsson; B. Gudbjornsson
• Keywords: Complement

The aim of this study was to investigate whether complement activation, via the classical and alternative pathways, occurs following a cemented total hip replacement (THR) surgery due osteoarthritis. Blood samples were collected systematically from 12 patients - six male women, with median age 75 (range: 59-90 years) preoperatively, 6 h post-operatively on first, second third post-operative day. Total function (CH50) pathways (AH50) evaluated, along determination serum concentrations proteins C3, C4, C3d, soluble terminal complex (sTCC) sC5b-9, as well C-reactive protein (CRP) albumin. Measurements CRP albumin levels elucidated marked inflammatory response operation. CH50, AH50 C3 C4 significantly lower after compared preoperative levels, but elevated above during 3 days. activation product C3d increased continually whole observation period, 13.5 AU/ml 8-19 AU/ml) 20 12-34 Furthermore, we observed an increase in sC5b-9 between These results demonstrate significant system THR. Further studies are needed elucidate time frame pathogenic role activation.