The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training

• DOI: 10.1111/sms.12055
• Publication Date: 2013-02-05T12:05:51Z
• Authors: R. M. Erskine; A. G. Williams; D. A. Jones; C. E. Stewart; H. Degens
• Keywords: Male; Heterozygote; Adolescent; Homozygote; Resistance Training; Organ Size; Peptidyl-Dipeptidase A; Polymorphism, Single Nucleotide; Quadriceps Muscle; RC1200; Young Adult; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Gene Frequency; INDEL Mutation; Isometric Contraction; Exercise Test; Humans; Actinin; Muscle Strength

Alternative measures of muscle size, strength, and power to those used in previous studies could help resolve the controversy surrounding associations between polymorphisms angiotensin‐ I converting enzyme ( ACE ) α‐actinin‐3 ACTN3 genes skeletal phenotypes, responses resistance training RT ). To this end, we measured quadriceps femoris volume V m ), physiological cross‐sectional area PCSA maximum isometric force F t specific per unit isoinertial strength (1‐ RM W max ; n = 40) before after 9‐week knee extension 51 previously untrained young men, who were genotyped for / D R577X polymorphisms. R ‐allele carriers had greater , 1‐ RM, than XX homozygotes at baseline (all P < 0.05), but independent genotype > 0.05). Muscle phenotypes 0.05) 0.01). However, people with “optimal” + combination compared “suboptimal” profile (both 0.0125). We show first time that polymorphism is associated human (independently polymorphism) influences .