A comprehensive cardiovascular disease risk profile in patients with schizophrenia

• DOI: 10.1111/sms.13371
• Publication Date: 2019-01-09T03:30:41Z
• Authors: Mathias Forsberg ...; Mona Nygård; Joshua Landen Taylor; Ismail Cüneyt Güzey; Gunnar Morken; Solveig Klæbo Reitan; Jørn Heggelund; Einar Vedul‐Kjelsaas; Eivind Wang
• Keywords: Adult; Blood Glucose; Male; Blood Pressure; Middle Aged; Overweight; Lipids; Body Mass Index; 3. Good health; 03 medical and health sciences; Oxygen Consumption; 0302 clinical medicine; Cardiovascular Diseases; Risk Factors; Case-Control Studies; Accelerometry; Exercise Test; Schizophrenia; Humans; Female; Waist Circumference; Exercise

Patients with schizophrenia are physically inactive and have high prevalence of cardiovascular disease (CVD). Peak oxygen uptake (V̇O 2peak ) is one the strongest predictors for CVD, yet rarely investigated in this patient population, how V̇O relates to other conventional CVD risk measures population unclear. We measured treadmill along daily physical activity assessed by triaxial accelerometry, body mass index (BMI), waist circumference, blood pressure, lipid profiles, glucose 48 outpatients (28 men, 35 ± 10 (SD) years; 20 women, 12 years), diagnosed schizophrenia, schizotypal, or delusional disorders (ICD‐10; F20‐29). The patients were compared age‐ sex‐matched healthy references (±2 years) normative data from population. was 34.5 8.7 mL/kg/min (men) 26.4 7.0 (women), which 27% 30% lower than references, respectively (both P < 0.01). not associated men while a weak association seen women (steps per day: r 2 = 0.26; counts minute: 0.25; 0.05). BMI (26.0 6.1 kg/m revealed that moderately overweight circumference 103 17 cm. Lipid‐ levels, pressure all within range. Our advocate utilization assessment profile determination schizophrenia. Daily poorly inconsistently related 2peak, suggesting increased might translate into improved reduction.