Effect of exercise training on heart rate variability in patients with obstructive sleep apnea: A randomized controlled trial

• DOI: 10.1111/sms.13447
• Publication Date: 2019-05-02T17:42:38Z
• Authors: Mathieu Berger; Jérémy Raffin; Vincent Pichot; David Hupin; Martin Garet; Pierre Labeix; Frédéric Costes; Jean‐Claude Barth...; Frédéric Roche
• Keywords: Male; Sleep Apnea, Obstructive; [SDV]Life Sciences [q-bio]; 610; 600; Heart; Middle Aged; Autonomic Nervous System; 3. Good health; 03 medical and health sciences; Oxygen Consumption; 0302 clinical medicine; Heart Rate; [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]; Humans; Female; [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing; Exercise; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; Aged

While obstructive sleep apnea (OSA) increases chemoreflex, leading to an autonomic dysfunction in the long term, no studies have yet assessed potential benefit of exercise on cardiac activity these patients. The aim this study was evaluate improvement function (CAF) measured through heart rate variability (HRV) after a 9-month physical program patients with OSA. Seventy-four moderate OSA, aged 40-80 years, were randomly assigned group (n = 36, 3 × 1 h/wk) or control 38) during 9 months. Linear and nonlinear HRV parameters night using Holter ECG. After months, mean R-R intervals increased without any changes parameters, while controls decreased global (standard deviation normal-to-normal intervals, total power) parasympathetic (root square successive difference N-Ns, very low frequency, high standard instantaneous beat-to-beat variability) indices (P < 0.05 for all). Significant correlations effect size found between severity 0.05). Improvement moderate-to-vigorous also correlated nocturnal oxygen In conclusion, supervised community may prevent decline nighttime CAF observed nontreated community-dwelling OSA over period. Thus, beyond apnea-hypopnea index improvement, be cardioprotective bradycardia, preservation, VO2peak increase.