An evaluation of mechanical and biophysical skin parameters at different body locations

• DOI: 10.1111/srt.13292
• Publication Date: 2023-02-18T17:50:25Z
• Authors: Anto J. U. K. John; Francesco Del Galdo; Rodney Gush; Peter R. Worsley
• Keywords: Transepidermal water loss; Skin type; Erythema

Skin is the largest organ in body, representing an important interface to monitor health and disease. However, there significant variation skin properties for different ages, genders body regions due differences structure morphology of tissues. This study aimed evaluate use non-invasive tools discriminate a range mechanical functional parameters from sites.A cohort 15 healthy volunteers was recruited following appropriate informed consent. Four well-established CE-marked techniques were used measure four anatomical regions: palm, forearm, sole lower lumbar L3, using repeated measures design. included trans-epidermal water loss (TEWL), pH (acidity), erythema, stratum corneum hydration stiffness elasticity Myoton Pro (skin muscle probe). Differences between locations each parameter intra-rater reliability days evaluated by same operator.The results indicate that differed significantly sites. For probe, recorded highest value 1006 N/m (SD ± 179), while least 484 160). The indenter probe revealed palm's 754 (± 108), 208 44). TEWL values lowest on averaging 11 g/m2/h, 41 g/m2/h. Similar levels three sites, with main difference being observed 13 arbitrary units. Erythema characterised high degree inter-subject variation, no sites or sides observed. showed excellent (intra-class correlation coefficients > 0.70) all exception one site right back; pro probes good poor (0.90-017), corneometer (>0.75) among tested, Good (0.74-0.4) sites.The methods, biophysical can be mapped, These reliably days, providing basis their assessing monitoring changes during