Association of HLA‐DRB1*09:01 with severe COVID‐19

• DOI: 10.1111/tan.14256
• Publication Date: 2021-03-18T10:31:49Z
• Authors: Alitzel Anzurez; Izumi Naka; Shoji Miki; Kaori Nakayama‐Ho...; Mariko Isshiki; Yusuke Watanabe; Midori Nakamura‐H...; Sayuri Seki; Takayuki Matsumura; Tomohiro Takano; Taishi Onodera; Yu Adachi; Saya Moriyama; Kazutaka Terahara; Natsuo Tachikawa; Yoshihiro Yoshimura; Hiroaki Sasaki; Hiroshi Horiuchi; Nobuyuki Miyata; Kazuhito Miyazaki; Michiko Koga; Kazuhiko Ikeuchi; Hiroyuki Nagai; Makoto Saito; Eisuke Adachi; Hiroshi Yotsuyanagi; Satoshi Kutsuna; Akira Kawashima; Yusuke Miyazato; Noriko Kinoshita; Chiyoko Kouno; Kensuke Tanaka; Yoshimasa Takahashi; Tadaki Suzuki; Tetsuro Matano; Jun Ohashi; Ai Kawana‐Tachikawa
• Keywords: HLA-DRB1

HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis 32 common alleles at four loci revealed a significant between HLA‐DRB1*09:01 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation value 0.0418]) when age, sex, other DRB1 locus adjusted. The DRB1*09:01 allele was more significantly associated risk for compared preexisting medical conditions such as hypertension, diabetes, cardiovascular diseases. These results indicate potential role predisposition