Polymorphism of the HLA system and weak antibody response to BNT162b2 mRNA vaccine

• DOI: 10.1111/tan.14546
• Publication Date: 2022-01-13T15:17:45Z
• Authors: Roberto Crocchiolo; Anna Maria Gallina; Arianna Pani; Daniela Campisi; Valeria Cento; Nicoletta Sacchi; Valeria Miotti; Oscar Matteo Gagl...; Federico D'Amico; Chiara Vismara; Giorgia Cornacchini; Giuliana Lando; Irene Cuppari; Francesco Scaglione; Silvano Rossini
• Keywords: Antibody response

The polymorphism of the HLA system has been extensively studied in COVID-19 infection, however there are no data about role on vaccine response. We report here HLA-A, -B, -C, and DRB1 allelic frequencies n = 111 individuals after BNT162b2 mRNA vaccine, selected basis lower antibody levels (<5% percentile) second dose among a total 2569 vaccinees, compare them with reference population. found that differences alleles HLA-A*03:01, A*33:03, B*58:01 at least one haplotype (HLA-A*24:02~C*07:01~B*18:01~DRB1*11:04) associated weaker response vaccination, together age vaccinees. Our results might suggest played by some or haplotypes production giving insights into tracking potentially susceptible across populations. Further studies needed to better define our exploratory findings dissect anti-COVID-19 vaccines.