Circulation and genetic diversity of Feline coronavirus type I andIIfrom clinically healthy andFIP‐suspected cats in China

• DOI: 10.1111/tbed.13081
• Publication Date: 2018-11-23T16:15:29Z
• Authors: Chunqiu Li; Qiujin Liu; Fanzhi Kong; Donghua Guo; Junjun Zhai; Mingjun Su; Dongbo Sun
• Keywords: Feline infectious peritonitis; Coronavirus

Feline infectious peritonitis (FIP) is a fatal disease of wild and domestic cats, the occurrence FIP frequently reported in China. To trace evolution type I II feline coronavirus China, 115 samples ascetic fluid from FIP-suspected cats 54 fecal clinically healthy were collected veterinary hospitals The presence FCoV was detected by RT-PCR targeting 6b gene. results revealed that total 126 (74.6%, 126/169) positive for FCoV: 75.7% (87/115) FCoV, 72.2% (39/54) FCoV. Of FCoV-positive samples, 95 partial S genes successfully sequenced. gene-based genotyping indicated accounted 95.8% (91/95) 4.2% (4/95), respectively. phylogenetic analyses showed 91 strains exhibited genetic diversity; four close relationship with Taiwan. Three strains, HLJ/HRB/2016/10, HLJ/HRB/2016/11 HLJ/HRB/2016/13, formed one potential new clade nearly complete genome-based trees. Further analysis infection appeared to be significantly correlated multi-cat environment (p < 0.01) age 0.01). gene three identified BJ/2017/27, BJ/2018/22 XM/2018/04, six nucleotide deletion (C4035AGCTC4040). Our data provide evidence co-circulate FIP-affected Type high prevalence diversity both (<6 months) associated infection.