IgA nephropathy is associated with Opisthorchis felineus liver fluke infection: Retrospective 5‐year analysis of human kidney samples

• DOI: 10.1111/tmi.14093
• Publication Date: 2025-02-03T02:23:57Z
• Authors: Anna Kovner; Yaroslav Kapushchak; Elena Hadieva; Mikhail Persidskij; Maria Pakharukova
• Keywords: Opisthorchis viverrini; Opisthorchis

Infection with the fish-borne liver fluke Opisthorchis felineus, which is transmitted through consumption of raw or undercooked fish, results in serious damage humans. Currently, limited clinical and experimental data reveal kidney co-occurring chronic opisthorchiasis. We conducted a retrospective analysis autopsy samples over five-year period (n = 84). The aim study was to assess pathomorphological changes kidneys evaluate whether there an association between IgA nephropathy infection. Histological analysis, immunohistochemistry, statistical were performed. In this study, we demonstrated for first time that O. felineus infection humans associated tubular dystrophy, accumulation renal casts, glomerulosclerosis. hypertension increases also detected total antigen glomeruli infected people. Fisher's test showed significant nephropathy, as well Therefore, findings highlight importance recognising more than hepatobiliary disease emphasise need careful, personalised monitoring function individuals.