Use of tranexamic acid results in decreased blood loss and decreased transfusions in patients undergoing staged bilateral total knee arthroplasty

• DOI: 10.1111/trf.12167
• Publication Date: 2013-03-23T06:31:49Z
• Authors: Todd C. Kelley; Kimberly K. Tucker; Mary Jo Adams; David F. Dalury
• Keywords: Antifibrinolytic

Background Tranexamic acid ( TXA ) is an antifibrinolytic that reduces blood loss and transfusion rates in total joint arthroplasty. Blood allogenic have not been well studied patients receiving undergoing bilateral staged knee arthroplasty TKA ). The purpose was to evaluate the effect of on loss, hemoglobin Hb changes, . Study Design Methods authors compared 51 who received (2 g; subjects) with 70 did (controls). There were no significant differences between groups terms demographics or preoperative For each , 1 g administered intravenously 15 minutes before incision at tourniquet release. levels, transfusions recorded. Statistical analyses performed using computer software. Significance set 0.05. Results Subjects had a significantly lower (p < 0.001) mean (±SD) (373.8 ± 264.6 mL vs. 871.6 457.7 ), higher 0.005) levels Postoperative Days 2, number transfused units (0.60 0.84 1.53 1.30 units). Conclusions improves postoperative decreases requirements for option choosing decrease risks associated when autologous available.