Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products

• DOI: 10.1111/trf.12827
• Publication Date: 2014-08-22T07:23:43Z
• Authors: Fredrick D. Oakley; Marcella Woods; Shanna Arnold; Pampee P. Young
• Keywords: Blood product; Cryoprecipitate; Transfusion reaction

Background The majority of reports on transfusion reactions address adult patients. Less is known about the types, incidence, and other clinical details in pediatric populations. Furthermore, to our knowledge, there have been no previous directly comparing these aspects between adults patient populations assess if are differences. Study Design Methods Between period January 1, 2011, February 2013, all reported at V anderbilt U niversity M edical C enter ( VUMC ) were evaluated by medicine service. information was subsequently shared with hemovigilance database. Data provided included age, sex, blood product associated reaction, severity type reactions. These collated hospital bank system–acquired data overall admission transfusion. Results A total 133,671 transfusions performed during study including 20,179 platelet PLT transfusions, 31,605 plasma 79,933 red cell RBC 2154 cryoprecipitate transfusions. Over same period, 108 277 recorded. This corresponds an incidence 6.2 per 1000 within (age < 21) population 2.4 population. In both populations, most commonly , followed then Within population, subset analysis identified multiple differences when compared increased allergic (2.7/1000 vs. 1.1/1000, p 0.001), febrile nonhemolytic (1.9/1000 0.47/1000, hypotensive (0.29/1000 0.078/1000, 0.05). Interestingly, while reaction sexes adults, patients, more common male patients (7.9/1000 males 4.3/1000 females, 0.01). Conclusion To knowledge this first provide detailed comparisons acute products a single institution supported service culture. Collectively insight into demonstrate general increase