Transfusion‐transmitted HBV infection with isolated anti‐HBs‐positive blood

• DOI: 10.1111/trf.17390
• Publication Date: 2023-05-02T12:48:57Z
• Authors: Masahiro Satake; Naoji Yamagishi; Ami Tanaka; Naoko Goto; Tomohiko Sakamoto; Yusuke Yanagino; Rika A. Furuta; Keiji Matsubayashi
• Keywords: Viremia; Hepatitis B; Infectivity

Hepatitis B virus (HBV)-positive individuals with isolated anti-HBs are found among HBV vaccine recipients and healthy blood donors no vaccination history. infectivity from transfusions derived such remains unclear.A male patient who received transfusion negative for individual donation-NAT, HBsAg anti-HBc but weakly positive developed typical transfusion-transmitted (TT)-HBV response. The responsible donor was a frequent repeat showing marked increase in titer without response 84 days after index donation. Test results his past donations showed transient viremia very low viral load fluctuating low-level anti-HBs. history of this unknown.Anti-HBs kinetics the suggest second antibody to new challenge, representing breakthrough case. On other hand, test suggested chronic occult infection anti-HBs.Whatever basic state, weak may include small population risk causing TT-HBV. Identifying harboring TT-HBV only is difficult under current screening strategies. Active surveillance occurrence necessary.