Effects of low‐dose cyclophosphamide with piroxicam on tumour neovascularization in a canine oral malignant melanoma‐xenografted mouse model

• DOI: 10.1111/vco.12059
• Publication Date: 2013-07-27T00:45:03Z
• Authors: N. Choisunirachon; T. Jaroensong; K. Yoshida; K. Saeki; M. Mochizuki; R. Nishimura; N. Sasaki; T. Nakagawa
• Keywords: Microvessel

Abstract Low‐dose cyclophosphamide ( CyLD ) has shown promise in the treatment of several cancers; however, effect on canine oral malignant melanoma never been explored. In this study, we investigated effects with or without piroxicam (Px) tumour neovascularization and vascular normalization a melanoma‐xenografted mice model. After , Px combination both CyPx ), growth groups was significantly suppressed compared to control group at 30 days treatment. Proliferation index also reduced by all treatments, only lowered microvessel density endothelial factor VEGF levels. Additionally, proportion normal vessels caused an imbalance between thrombospondin‐1. These results suggested that potent anti‐angiogenic terms number quality blood xenografted melanoma.