Clinical outcomes, ultrastructure and immunohistochemical features of canine high‐grade olfactory neuroblastoma

• DOI: 10.1111/vco.12512
• Publication Date: 2019-06-09T06:33:49Z
• Authors: Molly E. Church; Sridhar M. Veluvolu; Amy C. Durham; Kevin D. Woolard
• Keywords: Synaptophysin; Debulking; Esthesioneuroblastoma

Olfactory neuroblastoma (ONB) is a rare intranasal neoplasm in both dogs and humans. Similar clinical presentation overlapping histologic immunohistochemical features of ONB with other neoplasms can make diagnosis treatment neoplasia challenging. Furthermore, part because their rarity, there lack reporting on therapeutic regimen for these neoplasms. In humans, initial debulking surgery usually followed by radiation therapy. Here we report the histologic, immunohistochemical, ultrastructural characteristics canine progression cases treated all nine examined here, neoplastic cells were arranged lobular manner amidst prominent neurofibrillary matrix had consistent Grade III (high grade) ONB. The demonstrated positive staining TuJ-1, Class beta-tubulin neuronal cytoskeletal protein, variable markers, including chromogranin, synaptophysin, AE1/AE3 MAP2. longest surviving case was similar to that used consisting definitive Our study found TuJ-1 useful marker therapy, even advanced disease, may result prolonged survival.