Hematologic, prostaglandin F2α‐metabolite, serum amyloid A, and serum iron changes in horses with experimentally induced endotoxemia

• DOI: 10.1111/vcp.12870
• Publication Date: 2020-06-15T13:44:12Z
• Authors: Inger Lilliehöök; Johan Bröjer; Katarina Nostell; Hans Kindahl; Harold W. Tvedten; Anna Edner; Ragnvi Hagman
• Keywords: Neutrophilia; Monocytosis; Bolus (digestion)

Abstract Background Endotoxemia is a common and severe disease of horses. Most previous studies have monitored changes caused by bolus dose endotoxin over short time periods. Objectives We aimed to describe inflammatory responses with hematologic markers longer than has been performed in the past using more prolonged exposures. Methods Escherichia coli O55:B5 was administered as 6‐hour continuous intravenous infusion lipopolysaccharide (LPS) eight Blood cell counts, prostaglandin F 2α ‐metabolite (PGM), serum amyloid A (SAA), total iron concentrations were for up 3 or 6 days. Results An immediate decrease neutrophils monocytes occurred all horses, which subsequently changed moderate strong neutrophilia monocytosis that persisted 78 hours postinfusion (PI) LPS. Lymphocyte eosinophil numbers decreased gradually then normalized after 66‐ 78‐hours PI, respectively. Mild moderate, biphasic thrombocytopenia occurred. pronounced, transient increase PGM between 1 7 hours, peaking at 2 hours. Serum began PI remained elevated 72 PI. 48 The clinical signs most prominent during first 24 subsided within Conclusions Neutrophilia, monocytoses, high SAA present horses even had subsided. before SAA. Knowledge these findings imperative when interpreting laboratory results possible exposure.