Prospective evaluation of the acute patient physiologic and laboratory evaluation score and an extended clinicopathological profile in dogs with systemic inflammatory response syndrome

• DOI: 10.1111/vec.12257
• Publication Date: 2014-11-26T20:53:16Z
• Authors: Massimo Giunti; Roberta Troia; Paolo Famigli Ber...; Francesco Dondi
• Keywords: Hypoalbuminemia; Anion gap; Aspartate transaminase; Base excess

Abstract Objective To investigate the prognostic value of acute patient physiologic and laborartory evaluation (APPLE) score relevant clinicopathological markers in dogs with systemic inflammatory response syndrome (SIRS). Design Prospective observational cohort study. Setting Veterinary teaching hospital. Animals Thirty‐three SIRS admitted to intensive care unit (ICU) were compared 35 healthy control dogs. Dogs divided into septic ( n = 20) nonseptic 13) etiologies as survivors (alive discharge, 22) nonsurvivors 11: died, 6, or humanely euthanized, 5). Measurements Main Results For all dogs, physiological laboratory parameters prospectively collected for calculation APPLE fast score. No difference between was detected any parameter evaluated. Survivors had significantly higher total protein, albumin concentrations, antithrombin activity (ATA), base excess (BE), well lower lactate, urea, creatinine urinary protein ratio nonsurvivors. Higher values creatinine, anion gap, alanine transaminase (ALT), associated an increased risk death while albumin, ATA, BE a reduced mortality. When multivariate binary logistic regression analysis performed, only significant retained. Conclusions The determination clinical setting, measurement APP, BE, ALT, proteins, electrolytes may be beneficial better assessment SIRS. Identified related presence their should considered disease severity, guidance decision‐making process critically ill