Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles

• DOI: 10.1111/vox.12413
• Publication Date: 2016-05-17T11:17:17Z
• Authors: K. Isa; K. Sasaki; K. Ogasawara; M. Saito; H. Tsuneyama; R. Yabe; M. Uchikawa; M. Satake
• Keywords: 03 medical and health sciences; Phenotype; Polymorphism, Genetic; Rh-Hr Blood-Group System; 0302 clinical medicine; Japan; Mutation, Missense; Humans; Polymerase Chain Reaction; Alleles; Microsatellite Repeats

We identified 46 different RHD alleles from 226 Japanese individuals with weak D phenotype, 26 of which had been previously described and 20 that were novel. Among these individuals, the c.960G>A, c.845G>A ( *15 ) or c.1013T>C *01W.24 mutations most prevalent relative occurrences 36·7%, 15·9% 9·7%, respectively. These findings demonstrate prevalence common in population significantly differs Caucasian populations.