Impact of hepatitis E virus testing on the safety of blood components in Germany – results of a simulation study

• DOI: 10.1111/vox.12719
• Publication Date: 2018-10-15T04:29:52Z
• Authors: Christel Kamp; Johannes Blümel; Sally A. Baylis; Isabelle Bekeredj...; Michael Chudy; Margarethe Heiden; Olaf Henseler; Brigitte Keller‐S...; Anneke S. de Vos; Markus B. Funk
• Keywords: Hepatitis E Virus

Hepatitis E virus (HEV) infections may be acquired through transfusion of blood components. As transfusion-transmitted mostly affect vulnerable individuals, measures to ensure the supply safe components are under discussion. On basis epidemiological situation in Germany, different testing strategy scenarios were investigated simulation studies. Testing for HEV RNA by nucleic acid amplification technique (NAT) assays with a pool size 96, and 95% LoD 20 IU/ml will result an 80% reduction expected transmissions as well consequent chronic subsequent severe complications.