In vitro quality of cold and delayed cold‐stored platelet concentrates from interim platelet units during storage for 21 days

• DOI: 10.1111/vox.13437
• Publication Date: 2023-05-11T14:25:02Z
• Authors: Hanne Braathen; Turid Helen Felli...; Jörg Assmus; Kristin Gjerde Hagen; Einar Klæboe Kris...; Geir Strandenes; Torunn Oveland Ap...
• Keywords: Plateletpheresis; Platelet Transfusion; Blood bank; Blood preservation; Platelet concentrate; Interim

Abstract Background and Objectives Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality platelet function continuously cold‐stored delayed concentrates (PCs) from interim units (IPUs) produced by Reveos system. Materials Methods We used a pool‐and‐split design prepare 18 identical pairs of PCs. One unit was stored unagitated refrigerated after production day 1 (cold‐stored). The other agitated at room temperature until 5 then (delayed cold‐stored). Samples were taken days 5, 7, 14 21. Swirling observed haematology parameters, metabolism, blood gas, activation aggregation analysed for each sample point. Results All PCs complied with European recommendations (EDQM 20th edition). Both groups had mean content >200 × 10 9 /unit pH remained above 6.4 all points. Glucose concentration detectable every 21 14. group showed higher level before stimulation as measured flow cytometry. levels similar two stimulation. ability form aggregates cold storage Conclusion Our findings suggest that IPUs are suitable