Antibodies against glutamic acid decarboxylase in intravenous immunoglobulin preparations can affect the diagnosis of type 1 diabetes mellitus

• DOI: 10.1111/vox.13710
• Publication Date: 2024-07-03T00:53:55Z
• Authors: Tatsuki Miyamoto; Yuki Fukunaga; Ai Munakata; Katsushi Murai
• Keywords: Affect

Intravenous immunoglobulins (IVIgs) contain various autoantibodies, including those against glutamic acid decarboxylase (GADAb), a valuable biomarker of type 1 diabetes mellitus. Passive transfer GADAb from IVIgs to patients poses risk misdiagnosis, and information on the specific titres their impact diagnostic accuracy remains limited. This study aimed provide further insights into origin detected in patient serum following IVIg infusion.